People diagnosed with major depressive disorder who received repetitive transcranial magnetic stimulation (rTMS) had four response trajectories based on clinical characteristics, which may allow development of individualized treatment protocols. About 11% did not respond, 19% had a rapid response, 30% had higher baseline symptoms with a linear response, and 40% had lower baseline symptoms with a linear response. During the first week of treatment, significant differences in response and remission rates between trajectories were detectable. These findings were reported in “Trajectories of Response to Dorsolateral Prefrontal rTMS in Major Depression: A THREE-D Study” by Tyler S. Kaster , M.D . . .