October 7, 2010
Comparative Effectiveness of Treatment for Depression after Unsatisfactory Response to SSRIs when used as First-line Therapy
Researchers with the McMaster University Evidence Based Practice Center released a draft report that found that adding an atypical antipsychotic medication was
found to be an effective second step for persons first treated for depression with an SSRI, but who failed to respond. Higher response and remission rates after the
addition of an atypical antipsychotic, compared to adding a placebo, were supported by moderate grade evidence. Switching to another antidepressant was
supported by low-grade evidence, as was combining cognitive behavioral therapy with an antidepressant. Comments on the report will be accepted through
November 3, 2010.
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